Merit

Piramal Pharma Solutions

Facilitating the rapid scale-up of commercial ADC manufacturing for Piramal Pharma Solutions.

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In 2022, Piramal set out to rapidly expand its manufacturing capabilities in Grangemouth, Scotland, and chose Merit as its trusted construction partner. As a global leader in Antibody Drug Conjugate (ADC) and bio-conjugate manufacturing, Piramal’s vision was to increase production capacity and meet growing demand.

To bring this vision to life, we used our highly-advanced FLEXI POD® platform, merging traditional construction techniques with cutting-edge Modern Methods of Construction (MMC). By integrating offsite-manufactured PODs and Pre-Assembled Modules (PAMs), we ensured a faster, more efficient build without compromising quality.

Spanning 7,000m² across three floors, the new facility includes state-of-the-art Grade C production areas, modern offices, and a high-tech Quality Control laboratory, all designed to support Piramal’s world-class pharmaceutical operations. The expansion boosts the site’s capacity by an impressive 80%, paving the way for the scale-up of commercial ADC manufacturing.

Piramal’s decision to partner with Merit reflects their confidence in our fast-track approach, supported by a standard platform design that meets Medicines and Healthcare products Regulatory Agency (MHRA) requirements. Together, we have delivered a facility that strengthens global healthcare and advances life-changing therapies for patients.

  • Client: Piramal Pharma Solutions
  • Location: Grangemouth, Scotland
  • Sector: Life Sciences
  • Project: ADC Manufacturing Facility
  • Value: £35m

Key Features

– Delivery of a 7,000m2 3-storey facility comprises production areas, offices and quality control laboratory accommodation.
– Harnessed Merit’s highly-advanced FLEXI POD® solution.
– Piramal’s first Zero Scope 1 Carbon enabled facility
– Services layout configured to minimise plant room and distribution space – 50% saved on original consultant design.

Challenges and Solutions

– Rapid Delivery in Tight Timescales: Merit expedited project completion within a tight 18-month timeframe, meeting stringent deadlines with precision and efficiency.
– Cost Certainty Through Fixed Pricing: A commitment to fixed pricing ensured cost certainty throughout the project.
– Proactive Collaboration and Adaptation: During design workshops with Piramal, the need for additional lab equipment, specifically Nederman arms, emerged, which was not initially included in the tender drawings. Merit swiftly responded to Piramal’s requirement by engaging in collaborative discussions and promptly incorporating the necessary equipment details into the project scope.

Key Outcomes

– Achieved 80% Pre-Manufactured Value: This indicates a high degree of offsite manufacturing, significantly reducing onsite construction time and labour.
– Delivered £35m facility to budget
– Project completion achieved within 18 months, achieved 2.5 years faster than traditional methods of construction
– Piramal’s first Zero Scope 1 Carbon enabled facility, BREEAM Excellent and EPC-A: The facility meets high environmental standards, with certifications reflecting its sustainability and energy efficiency.